“My point here is that if they believe that Donald Trump cannot fulfill the obligations of his office, then they have a constitutional responsibility to invoke the 25th amendment,” Warren, a Democratic presidential candidate, said after a rally in Las Vegas. “Their loyalty under law is not to him personally. It is to the Constitution of the United States and to the people of United States.”
The 25th Amendment, proposed by Congress and ratified by the states in the aftermath of the assassination of President John F. Kennedy, provides the procedures for replacing the president or vice president in the event of death, removal, resignation, or incapacitation.
The VP has to support the removal of the President and a majority of Congress or the Executive Branch has to agree. Additionally the 25th Amendment isn’t a political weapon; it is a means for replacing a President who can no longer perform his duties.